Description

5-(Trifluoromethyl)-2,3-Dihydro-1H-Inden-1-Amine Hydrochloride is a high-purity, pharmaceutically relevant intermediate characterized by its indane core and trifluoromethyl group. This compound matters as a critical building block in modern medicinal chemistry, where the trifluoromethyl moiety is prized for its ability to enhance metabolic stability, lipophilicity, and bioavailability in target molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular targets.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of novel drug candidates targeting G-protein-coupled receptors (GPCRs).
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization programs due to its unique physicochemical properties.
• API Development: A crucial precursor in multi-step synthetic routes for potential therapeutics in neurology and psychiatry.
• Chemical Biology: Employed as a probe or labeled compound for studying biological pathways and enzyme interactions.
• Process Chemistry: Used in scaling up synthetic routes from laboratory to pilot plant scale under GMP-like conditions.
• Custom Synthesis: A starting material for the preparation of more complex, functionalized indane derivatives for specialized client projects.

Basic Information

Product Name	5-(Trifluoromethyl)-2,3-Dihydro-1H-Inden-1-Amine Hydrochloride
CAS No.	936220-73-4
Molecular Formula	C10H11ClF3N
Molecular Weight	237.65 g/mol
Synonyms	1-Amino-5-(trifluoromethyl)indane hydrochloride; 5-(Trifluoromethyl)-1-indanamine hydrochloride; 5-(Trifluoromethyl)indan-1-amine HCl; 1-Indanamine, 5-(trifluoromethyl)-, hydrochloride; 5-Trifluoromethyl-2,3-dihydro-1H-inden-1-amine hydrochloride; (1R/S)-5-(Trifluoromethyl)-2,3-dihydro-1H-inden-1-amine hydrochloride
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)-2,3-Dihydro-1H-Inden-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via NMR and MS, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.