Description

(R)-tert-Butyl (1-(5-Fluoro-4-Oxo-3-Phenyl-3,4-Dihydroquinazolin-2-Yl)Propyl)Carbamate is a high-purity, advanced pharmaceutical intermediate characterized by its chiral center and complex heterocyclic structure. This compound is critical for the synthesis of targeted therapeutic agents, offering researchers and manufacturers a reliable building block for complex molecular architectures. It is primarily utilized in the research and development of novel active pharmaceutical ingredients (APIs), particularly within oncology and other specialized therapeutic areas.

Application

• Key Intermediate in API Synthesis: Serves as a crucial chiral building block in the multi-step synthesis of complex drug candidates.
• Oncology Research: Used in the development and scale-up of novel chemotherapeutic agents and targeted cancer therapies.
• Pharmaceutical Process Development: Employed in route scouting, optimization, and pilot-scale manufacturing for new chemical entities (NCEs).
• Preclinical & Clinical Trial Material Production: Supplied for the preparation of batches required for toxicology studies and early-phase clinical trials.
• Asymmetric Synthesis: Utilized in reactions requiring high enantioselectivity due to its defined (R)-configuration.
• Chemical Biology & Medicinal Chemistry: Acts as a scaffold for creating compound libraries to study structure-activity relationships (SAR).

Basic Information

Product Name	(R)-tert-Butyl (1-(5-Fluoro-4-Oxo-3-Phenyl-3,4-Dihydroquinazolin-2-Yl)Propyl)Carbamate
CAS No.	936025-37-5
Molecular Formula	C22H24FN3O3
Molecular Weight	397.45 g/mol
Synonyms	(R)-tert-Butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbamate; Boc-(R)-1-(5-Fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propylamine; N-Boc-1-(5-Fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)-(R)-propylamine; tert-Butyl N-[(1R)-1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl]carbamate; 936025-37-5; (R)-Boc-protected quinazolinone derivative
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl (1-(5-Fluoro-4-Oxo-3-Phenyl-3,4-Dihydroquinazolin-2-Yl)Propyl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to confirm enantiomeric purity and comprehensive identification and assay methods. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with the stringent requirements of pharmaceutical R&D and cGMP guidelines for intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.