Description

2-Nitro-5-Fluoropyridine n-Oxide is a high-purity, versatile heterocyclic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both nitro and fluorine substituents on the pyridine N-oxide core, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and anti-infective agents.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of the fluorinated pyridine scaffold.
• Material Science Research: Serves as a building block for creating specialized ligands, polymers, and functionalized materials with specific electronic properties.
• Chemical Biology & Proteomics: Employed as a reactive handle or tagging agent in probe development for studying biological systems and protein interactions.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce complex aromatic systems.
• Nucleophilic Aromatic Substitution: The activated nitro and fluorine groups make it an excellent electrophile for nucleophilic substitution reactions to create diverse chemical libraries.

Basic Information

Product Name	2-Nitro-5-Fluoropyridine n-Oxide
CAS No.	935753-02-9
Molecular Formula	C5H3FN2O3
Molecular Weight	158.09 g/mol
Synonyms	5-Fluoro-2-nitropyridine 1-Oxide; 2-Nitro-5-fluoropyridine 1-Oxide; 5-Fluoro-2-nitropyridine N-Oxide; Pyridine, 5-fluoro-2-nitro-, 1-oxide; 935753-02-9
EINECS	Contact for details

Quality Control

Every batch of 2-Nitro-5-Fluoropyridine n-Oxide is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation and to minimize degradation.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.