Description

N–(4–Pentynoyl) Mannosamine Tetraacylated (Ac4Mannal) is a chemically modified monosaccharide derivative, specifically a peracetylated mannosamine analog bearing a terminal alkyne handle. This compound matters as a critical metabolic chemical reporter and bioorthogonal precursor, enabling the selective labeling and study of cell-surface glycans. Researchers in chemical biology, glycobiology, and drug discovery need it for applications such as metabolic oligosaccharide engineering, glycan imaging, and the development of targeted therapeutics.

Application

• Metabolic Oligosaccharide Engineering (MOE): Acts as a metabolic precursor for the bioorthogonal labeling of sialic acid-containing glycans on cell surfaces.
• Glycoproteomics and Glycomics Research: Enables the enrichment, identification, and profiling of newly synthesized glycoproteins via click chemistry conjugation.
• Live-Cell Imaging: Used to visualize dynamic glycan expression and trafficking in real-time using fluorescent azide probes.
• Drug Discovery & Targeted Delivery: Serves as a building block for synthesizing antibody-drug conjugates (ADCs) or other targeted agents that home to specific glycosylation patterns.
• Virus-Host Interaction Studies: Facilitates the study of viral entry mechanisms that involve sialylated receptors.
• Biomaterial Functionalization: Used to introduce bio-recognition elements onto surfaces for biosensor development or tissue engineering scaffolds.

Basic Information

Product Name	N–(4–Pentynoyl) Mannosamine Tetraacylated (Ac4Mannal)
CAS No.	935658-93-8
Molecular Formula	C23H29NO11
Molecular Weight	495.48 g/mol
Synonyms	Ac4ManAl; Tetra-O-acetyl-N-(4-pentynoyl)-D-mannosamine; N-(4-Pentynoyl)-2-acetamido-2-deoxy-D-mannose tetraacetate; Peracetylated N-Pentynoylmannosamine; 1,3,4,6-Tetra-O-acetyl-2-deoxy-2-[(4-pentynoylamino)]-D-mannopyranose; Metabolic Labeling Reagent Ac4ManAl; Chemical Reporter for Sialic Acid; Ac4ManNAl
EINECS	Contact for details

Quality Control

Our N–(4–Pentynoyl) Mannosamine Tetraacylated is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under desiccant. The product is moisture-sensitive and should be allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, Chloroform

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.