Description

tert-Butyl 1-Oxa-5-Azaspiro[2.3]Hexane-5-Carboxylate is a high-value, protected spirocyclic building block used in advanced organic synthesis. This compound is critical for medicinal chemistry research and the development of novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Scaffold: Used to introduce the constrained 1-oxa-5-azaspiro[2.3]hexane moiety, which can improve metabolic stability and binding affinity in lead optimization.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker component for constructing bifunctional molecules in targeted protein degradation research.
• Agrochemical Synthesis: Employed in the research and development of new-generation herbicides and fungicides with spirocyclic structures.
• Academic & Contract Research: A valuable reagent for methodology development and exploring new chemical space in university and CRO laboratories.
• Peptidomimetics: Facilitates the creation of conformationally restricted peptide analogs for biochemical studies.

Basic Information

Product Name	tert-Butyl 1-Oxa-5-Azaspiro[2.3]Hexane-5-Carboxylate
CAS No.	934664-42-3
Molecular Formula	C10H17NO3
Molecular Weight	199.25 g/mol
Synonyms	5-Boc-1-oxa-5-azaspiro[2.3]hexane; 1-Oxa-5-azaspiro[2.3]hexane-5-carboxylic acid, 1,1-dimethylethyl ester; tert-Butyl 1-oxa-5-azaspiro[2.3]hexane-5-carboxylate; Boc-1-oxa-5-azaspiro[2.3]hexane; 5-(tert-Butoxycarbonyl)-1-oxa-5-azaspiro[2.3]hexane; Spiro[oxirane-2,2'-azetidine], 1'-(1,1-dimethylethyl) 1'-carbamate (9CI)
EINECS	Contact for details

Quality Control

Our tert-Butyl 1-Oxa-5-Azaspiro[2.3]Hexane-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for sensitive pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.