Description

R-1-n-Cbz-Propane-1,2-Diamine-Hcl is a protected diamine derivative, specifically the hydrochloride salt of the Cbz (carbobenzyloxy)-protected (R)-1,2-diaminopropane. This compound serves as a crucial chiral building block in organic synthesis, offering a protected primary amine group for controlled reactivity. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and fine chemical industries for the synthesis of active pharmaceutical ingredients (APIs), chiral ligands, and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of drug candidates, particularly those requiring a diamino-propane backbone.
• Peptide Mimetics & Modifications: Used to introduce chiral diamine structures into peptide chains to alter biological activity and stability.
• Ligand Synthesis: Serves as a precursor for the preparation of chiral ligands used in asymmetric catalysis (e.g., for hydrogenation or cross-coupling reactions).
• Chemical Research: Employed in academic and industrial R&D for exploring new synthetic methodologies and constructing molecular libraries.
• Fine Chemical Production: Integral in the multi-step synthesis of complex, high-value specialty chemicals.

Basic Information

Product Name	R-1-n-Cbz-Propane-1,2-Diamine-Hcl
CAS No.	934634-53-4
Molecular Formula	C11H17ClN2O2
Molecular Weight	244.72 g/mol
Synonyms	(R)-1-(((Benzyloxy)carbonyl)amino)propan-2-amine hydrochloride; (R)-2-Amino-1-((((benzyloxy)carbonyl)amino)methyl)ethylamine hydrochloride; (R)-1-Cbz-1,2-diaminopropane hydrochloride; (R)-N1-Cbz-1,2-diaminopropane hydrochloride; (R)-Nα-Cbz-1,2-diaminopropane hydrochloride; (R)-1-(Benzyloxycarbonylamino)-2-aminopropane hydrochloride; (R)-Cbz-DAP.HCl; (R)-1,2-Diaminopropane-1-Cbz hydrochloride
EINECS	Contact for details

Quality Control

Our R-1-n-Cbz-Propane-1,2-Diamine-Hcl is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical purity, correct stereochemistry, and consistent performance. Standard testing includes chiral purity analysis (HPLC), identity confirmation (IR, NMR), and assay determination. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.