Description

3-(Cbz-Amino)-D-Alanine Methyl Ester Hcl is a protected D-amino acid derivative, specifically the methyl ester hydrochloride salt of Cbz-protected D-alanine. This compound is a crucial chiral building block in the synthesis of complex peptides and peptidomimetics, offering high enantiomeric purity for advanced pharmaceutical research. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including protease inhibitors and bioactive peptides.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce a protected D-alanine residue into peptide chains.
• Protease Inhibitor Development: Serves as a building block for creating inhibitors targeting specific proteolytic enzymes.
• Chemical Biology Research: Employed in the study of protein-protein interactions and the structure-activity relationships (SAR) of peptides.
• Asymmetric Synthesis: Utilized in the preparation of non-natural amino acids and other chiral molecules for medicinal chemistry.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	3-(Cbz-Amino)-D-Alanine Methyl Ester Hcl
CAS No.	934587-44-7
Molecular Formula	C12H16N2O4 • HCl
Molecular Weight	288.73 g/mol
Synonyms	N-Carbobenzoxy-D-alanine methyl ester hydrochloride; (R)-Methyl 2-((((benzyloxy)carbonyl)amino)propanoate hydrochloride; D-Alanine, N-[(phenylmethoxy)carbonyl]-, methyl ester, hydrochloride; Cbz-D-Ala-OMe • HCl; Z-D-Ala-OMe • HCl; Methyl N-carbobenzoxy-D-alaninate hydrochloride; (R)-Methyl 2-(((benzyloxy)carbonyl)amino)propanoate hydrochloride
EINECS	Contact for details

Quality Control

Our 3-(Cbz-Amino)-D-Alanine Methyl Ester Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical research. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.