Description

6-Bromo-1,4-Dihydro-7-Fluoro-1-[(1S)-1-(Hydroxymethyl)-2-Methylpropyl]-4-Oxo-3-Quinolinecarboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate with a defined stereochemistry. This compound is critical for the synthesis of novel fluoroquinolone antibiotics, offering a key chiral building block for research and development. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers targeting anti-infective drug discovery and production.

Application

• Key Intermediate in Fluoroquinolone Synthesis: Serves as a crucial chiral precursor in the development of next-generation broad-spectrum antibacterial agents.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the creation of novel antibiotic candidates.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the scaled-up production of specific, potent fluoroquinolone-class APIs.
• Process Chemistry & Route Scouting: Utilized by chemists to develop and optimize efficient, stereoselective synthetic pathways.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical development.

Basic Information

Product Name	6-Bromo-1,4-Dihydro-7-Fluoro-1-[(1S)-1-(Hydroxymethyl)-2-Methylpropyl]-4-Oxo-3-Quinolinecarboxylic Acid Ethyl Ester
CAS No.	934161-50-9
Molecular Formula	C18H21BrFNO4
Molecular Weight	414.27 g/mol
Synonyms	Ethyl 6-Bromo-1,4-dihydro-7-fluoro-1-[(1S)-1-(hydroxymethyl)-2-methylpropyl]-4-oxo-3-quinolinecarboxylate; (S)-Ethyl 6-bromo-1,4-dihydro-7-fluoro-1-(1-hydroxymethyl-2-methylpropyl)-4-oxo-3-quinolinecarboxylate; 6-Bromo-7-fluoro-1-((S)-1-hydroxymethyl-2-methylpropyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester; BOC-Protected Fluoroquinolone Intermediate; Chiral Fluoroquinolone Ester; 934161-50-9
EINECS	Contact for details

Quality Control

Our 6-Bromo-1,4-Dihydro-7-Fluoro-1-[(1S)-1-(Hydroxymethyl)-2-Methylpropyl]-4-Oxo-3-Quinolinecarboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.