Description

tert-Butyl 4-Hydroxy-3,4-Dihydro-2H-Quinoline-1-Carboxylate is a high-purity, protected heterocyclic building block of significant interest in advanced organic synthesis. This compound serves as a versatile and critical intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for API synthesis and novel compound libraries.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel quinoline-based active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in the design and construction of compound libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Process Chemistry: Serves as a protected precursor in scalable route development for target molecules, leveraging the acid-labile tert-butyloxycarbonyl (Boc) protecting group.
• Agrochemical Synthesis: Employed as a building block for developing new crop protection agents and pesticides with heterocyclic cores.
• Fine Chemical Production: Utilized in the custom synthesis of specialty chemicals, dyes, and functional materials.

Basic Information

Product Name	tert-Butyl 4-Hydroxy-3,4-Dihydro-2H-Quinoline-1-Carboxylate
CAS No.	932398-74-8
Molecular Formula	C14H17NO3
Molecular Weight	247.29 g/mol
Synonyms	1-Boc-4-hydroxy-1,2,3,4-tetrahydroquinoline; 4-Hydroxy-3,4-dihydro-2H-quinoline-1-carboxylic acid tert-butyl ester; tert-Butyl 4-hydroxy-1,2,3,4-tetrahydroquinoline-1-carboxylate; 1,2,3,4-Tetrahydro-4-hydroxyquinoline-1-carboxylic acid tert-butyl ester; Boc-4-hydroxy-THQ; 4-Hydroxy-THQ-Boc; 1-N-Boc-4-hydroxy-1,2,3,4-tetrahydroquinoline
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Hydroxy-3,4-Dihydro-2H-Quinoline-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.