Description

1-Chloro-4-Fluoro-2-Methoxy-5-Nitro-Benzene is a high-purity, multi-functional aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a valuable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those containing fluorine and nitro groups for enhanced bioactivity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where its halogenated structure contributes to product efficacy.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Intermediate: Employed in the manufacture of complex dyes and organic pigments due to its nitro and methoxy substituents.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create biaryl structures.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D labs exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	1-Chloro-4-Fluoro-2-Methoxy-5-Nitro-Benzene
CAS No.	932374-66-8
Molecular Formula	C7H5ClFNO3
Molecular Weight	205.57 g/mol
Synonyms	2-Chloro-5-Fluoro-4-Methoxy-1-Nitrobenzene; 4-Chloro-1-Fluoro-2-Methoxy-5-Nitrobenzene; 5-Nitro-2-Chloro-4-Fluoroanisole; 1-Chloro-4-fluoro-2-methoxy-5-nitrobenzene; Benzene, 1-chloro-4-fluoro-2-methoxy-5-nitro-; 2-Methoxy-5-nitro-4-fluorochlorobenzene
EINECS	Contact for details

Quality Control

Our 1-Chloro-4-Fluoro-2-Methoxy-5-Nitro-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.