Description

8-Chlorosulfonyl-1,4-Dioxa-Spiro[4.5]Dec-7-Ene-7-Carboxylic Acid Ethyl Ester is a high-value, multifunctional spirocyclic building block designed for advanced synthetic chemistry. Its unique structure, featuring a reactive chlorosulfonyl group and a protected carbonyl, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel spirocyclic drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Agrochemical Synthesis: Used in the research and development of new herbicides and fungicides with spirocyclic motifs for enhanced efficacy and environmental profile.
• Chemical Biology Probe Development: The reactive sulfonyl chloride moiety allows for selective conjugation, making it useful for creating activity-based probes and protein labeling reagents.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of specialty polymers with unique thermal or mechanical properties.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex molecules for clients.

Basic Information

Product Name	8-Chlorosulfonyl-1,4-Dioxa-Spiro[4.5]Dec-7-Ene-7-Carboxylic Acid Ethyl Ester
CAS No.	929557-84-6
Molecular Formula	C11H15ClO6S
Molecular Weight	310.75 g/mol
Synonyms	Ethyl 8-(chlorosulfonyl)-1,4-dioxaspiro[4.5]dec-7-ene-7-carboxylate; 1,4-Dioxaspiro[4.5]dec-7-ene-7-carboxylic acid, 8-(chlorosulfonyl)-, ethyl ester; 8-Chlorosulfonyl-1,4-dioxaspiro[4.5]dec-7-ene-7-carboxylic acid ethyl ester; Spirocyclic sulfonyl chloride ester; Ethyl 8-chlorosulfonyl-1,4-dioxaspiro[4.5]dec-7-ene-7-carboxylate
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our advanced intermediates. Every batch of 8-Chlorosulfonyl-1,4-Dioxa-Spiro[4.5]Dec-7-Ene-7-Carboxylic Acid Ethyl Ester is analyzed using validated methods (HPLC, NMR, IR) to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.