Description

5-Bromo-1,2,3,4-tetrahydroquinoline-8-carboxylic acid is a high-purity, synthetically valuable heterocyclic building block, specifically a brominated tetrahydroquinoline derivative. This compound is essential for advanced organic synthesis, serving as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and functional materials. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides due to its bioactive quinoline scaffold.
• Material Science: Serves as a building block for organic ligands, dyes, and photoactive materials in advanced electronic applications.
• Academic & Contract Research: Employed in medicinal chemistry programs and process development for structure-activity relationship (SAR) studies.
• Chemical Synthesis: Utilized in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce complex functionalities.

Basic Information

Product Name	5-Bromo-1,2,3,4-tetrahydroquinoline-8-carboxylic acid
CAS No.	928839-65-0
Molecular Formula	C10H10BrNO2
Molecular Weight	256.10 g/mol
Synonyms	8-Bromo-5,6,7,8-tetrahydroquinoline-3-carboxylic Acid; 5-Bromo-1,2,3,4-tetrahydro-8-quinolinecarboxylic Acid; 5-Bromo-8-carboxy-1,2,3,4-tetrahydroquinoline; 928839-65-0; 5-Bromo-THQ-8-COOH
EINECS	Contact for details

Quality Control

Our production of 5-Bromo-1,2,3,4-tetrahydroquinoline-8-carboxylic acid adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) detailing all specifications is supplied with each shipment, and custom synthesis to meet specific pharmacopeial or internal standards is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.