Description

6-Chloro-7-Methylspiro[Chroman-2,4'-Piperidin]-4-One is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic structure. This compound is of significant value in medicinal chemistry for its role as a versatile building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of proprietary drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties of lead molecules.
• CNS Drug Development: Employed in the research and synthesis of potential therapeutics for neurological disorders, leveraging its spirocyclic piperidine moiety.
• Oncology Research: Utilized in the construction of molecular libraries for screening against cancer cell lines and specific biological targets.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical companies in early-stage drug discovery and process development.
• Academic Research: Used in university and institutional labs for fundamental studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	6-Chloro-7-Methylspiro[Chroman-2,4'-Piperidin]-4-One
CAS No.	927978-42-5
Molecular Formula	C14H16ClNO2
Molecular Weight	265.74 g/mol
Synonyms	6-Chloro-7-methylspiro[chroman-2,4'-piperidin]-4-one; 4H-Spiro[chromene-2,4'-piperidin]-4-one, 6-chloro-7-methyl-; 6-Chloro-7-methyl-4H-spiro[chromene-2,4'-piperidin]-4-one; Spiro[chroman-2,4'-piperidin]-4-one, 6-chloro-7-methyl-; 927978-42-5; 6-Chloro-7-methylspiro(chroman-2,4'-piperidin)-4-one
EINECS	Contact for details

Quality Control

Our 6-Chloro-7-Methylspiro[Chroman-2,4'-Piperidin]-4-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to ensure the material meets the stringent requirements for pharmaceutical R&D and process chemistry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.