Description

6-Bromo-4-Iodoquinoline is a high-purity halogenated quinoline derivative, a crucial building block in advanced organic synthesis. This compound is valued for its dual halogen functionality, which enables selective cross-coupling reactions and facilitates the construction of complex heterocyclic architectures. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for developing active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel quinoline-based drug candidates, including potential kinase inhibitors and antimicrobial agents.
• Agrochemical Research: Used to develop new crop protection compounds and herbicides by exploiting the quinoline scaffold's bioactivity.
• Material Science: Serves as a monomer or functionalizing agent in the creation of organic semiconductors, ligands for metal-organic frameworks (MOFs), and luminescent materials.
• Cross-Coupling Reactions: The bromo and iodo substituents act as orthogonal handles for sequential Suzuki-Miyaura, Buchwald-Hartwig, or other palladium-catalyzed coupling reactions.
• Chemical Biology: Employed as a molecular probe or tag in medicinal chemistry programs for structure-activity relationship (SAR) studies.
• Academic & Industrial R&D: A versatile reagent for methodological development in organic chemistry and scale-up process optimization.

Basic Information

Product Name	6-Bromo-4-Iodoquinoline
CAS No.	927801-23-8
Molecular Formula	C9H5BrIN
Molecular Weight	333.96 g/mol
Synonyms	4-Iodo-6-bromoquinoline; Quinoline, 6-bromo-4-iodo-; 6-Bromo-4-iodoquinoline; 927801-23-8; 4-Iodo-6-bromo-quinoline; 6-Brom-4-jodchinolin (German); 6-ブロモ-4-ヨードキノリン (Japanese)
EINECS	Contact for details

Quality Control

Our 6-Bromo-4-Iodoquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.