Description

4-Bromo-8-Chloroquinoline-3-Carboxylic Acid Ethyl Ester is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. This compound serves as a critical intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, enabling the construction of complex quinoline-based molecular architectures. It is primarily sought by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for its versatile reactivity.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel quinoline-based drug candidates, including potential antimicrobials, anticancer agents, and kinase inhibitors.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of the halogenated quinoline core.
• Material Science: Building block for creating functional organic materials, such as ligands for metal-organic frameworks (MOFs) or organic semiconductors.
• Chemical Synthesis: Versatile reagent for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and further functionalization due to the reactive bromo and chloro substituents.
• Academic & R&D: Essential for medicinal chemistry programs and methodological studies in universities and contract research organizations (CROs).

Basic Information

Product Name	4-Bromo-8-Chloroquinoline-3-Carboxylic Acid Ethyl Ester
CAS No.	927800-77-9
Molecular Formula	C₁₂H₉BrClNO₂
Molecular Weight	314.56 g/mol
Synonyms	Ethyl 4-Bromo-8-chloroquinoline-3-carboxylate; 4-Bromo-8-chloro-quinoline-3-carboxylic acid ethyl ester; 8-Chloro-4-bromoquinoline-3-carboxylic acid ethyl ester; 3-Quinolinecarboxylic acid, 4-bromo-8-chloro-, ethyl ester; Ethyl 4-bromo-8-chloro-3-quinolinecarboxylate; 4-Bromo-8-chloro-3-quinolinecarboxylic acid ethyl ester; 927800-77-9; 4-Bromo-8-chloroquinoline-3-carboxylate ethyl ester
EINECS	Contact for details

Quality Control

Our 4-Bromo-8-Chloroquinoline-3-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.