Description

4-Chloro-6-Trifluoromethoxyquinoline is a high-value, multi-functional heterocyclic building block characterized by its halogenated and fluorinated alkoxy substituents. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, where its unique structure imparts desirable biological activity and metabolic stability. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of quinoline-based drug candidates, including potential kinase inhibitors and antimicrobial agents.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, leveraging the trifluoromethoxy group for enhanced lipophilicity and bioactivity.
• Material Science Research: Used in the development of organic electronic materials, such as OLEDs and semiconductors, due to its electron-deficient quinoline core.
• Chemical Biology Probes: Serves as a fluorescent tag or a pharmacophore in the design of molecular probes for biochemical assays.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific synthetic routes and scale-up projects.

Basic Information

Product Name	4-Chloro-6-Trifluoromethoxyquinoline
CAS No.	927800-55-3
Molecular Formula	C₁₀H₅ClF₃NO
Molecular Weight	247.60 g/mol
Synonyms	4-Chloro-6-(trifluoromethoxy)quinoline; 6-Trifluoromethoxy-4-chloroquinoline; Quinoline, 4-chloro-6-(trifluoromethoxy)-; 4-Chloro-6-trifluoromethoxy-quinoline; 4-Chloro-6-trifluoromethoxyquinoline; 4-Chloro-6-(trifluoromethoxy)quinoline (CAS 927800-55-3)
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-6-Trifluoromethoxyquinoline is manufactured under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly closed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.