Description

4-Chloro-8-Fluoro-2-Trichloromethylquinoline is a high-value, multi-halogenated quinoline derivative that serves as a critical synthetic intermediate. Its unique halogen substitution pattern makes it a versatile building block for constructing complex molecular architectures, particularly in advanced pharmaceutical and agrochemical research. This compound is essential for R&D chemists and process development scientists working in medicinal chemistry, crop protection, and materials science.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting infectious diseases or central nervous system disorders.
• Agrochemical Synthesis: Building block for developing next-generation fungicides, herbicides, and insecticides with enhanced activity and selectivity.
• Material Science Research: Used in the development of organic semiconductors, light-emitting diodes (OLEDs), and other functional organic materials.
• Chemical Biology Probes: Serves as a core structure for creating fluorescent tags or molecular probes to study biological processes.
• Catalyst Ligand Development: Potential precursor for synthesizing novel ligands used in transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke chemical synthesis projects.

Basic Information

Product Name	4-Chloro-8-Fluoro-2-Trichloromethylquinoline
CAS No.	927800-48-4
Molecular Formula	C11H4Cl4FN
Molecular Weight	313.97 g/mol
Synonyms	2-(Trichloromethyl)-4-chloro-8-fluoroquinoline; 4-Chloro-8-fluoro-2-(trichloromethyl)quinoline; 8-Fluoro-4-chloro-2-trichloromethylquinoline; Quinoline, 4-chloro-8-fluoro-2-(trichloromethyl)-; CAS 927800-48-4
EINECS	Contact for details

Quality Control

Our 4-Chloro-8-Fluoro-2-Trichloromethylquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC-MS for impurity profiling. We provide full traceability and Certificates of Analysis (COA) are available for every shipment to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.