Description

4-Bromo-8-Fluoroquinoline is a high-value halogenated quinoline derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its unique structure, featuring both bromine and fluorine substituents, makes it an essential building block for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel quinolone-based antibiotics and other therapeutic agents targeting bacterial infections.
• Agrochemical Research: Used in the development of new fungicides and herbicides, where the halogenated quinoline core contributes to biological activity.
• Material Science: Serves as a building block for organic semiconductors, liquid crystals, and fluorescent dyes due to its electron-deficient aromatic system.
• Chemical Synthesis: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce the quinoline scaffold into more complex molecular architectures.
• Ligand Preparation: Acts as a starting material for synthesizing specialized nitrogen-containing ligands used in catalysis.

Basic Information

Product Name	4-Bromo-8-Fluoroquinoline
CAS No.	927800-38-2
Molecular Formula	C9H5BrFN
Molecular Weight	226.05 g/mol
Synonyms	8-Fluoro-4-bromoquinoline; Quinoline, 4-bromo-8-fluoro-; 4-Bromo-8-fluoro-quinoline; 4-Bromo-8-fluoroquinoline; 927800-38-2
EINECS	Contact for details

Quality Control

Our 4-Bromo-8-Fluoroquinoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We adhere to cGMP standards where applicable to support our clients in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.