Description

(R)-6,7-Dimethoxy-4-(3-(Quinoxalin-2-Yloxy)Pyrrolidin-1-Yl)Quinazoline is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and complex heterocyclic structure. This compound is of significant value in the research and development of novel therapeutic agents, particularly as a key building block for targeted kinase inhibitors. It is primarily utilized by pharmaceutical R&D departments, biotechnology firms, and contract research organizations (CROs) engaged in oncology and signal transduction pathway research.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral precursor in the synthesis of investigational new drugs (INDs) and active pharmaceutical ingredients (APIs).
• Kinase Inhibitor Research: Used as a core scaffold in the design and development of potent and selective kinase inhibitors for oncology targets.
• Biochemical Assay Development: Employed as a reference standard or probe compound in high-throughput screening (HTS) and enzymatic activity studies.
• Medicinal Chemistry Optimization: Provides a versatile template for structure-activity relationship (SAR) studies to optimize pharmacokinetic and pharmacodynamic properties.
• Academic Research: Utilized in university and institutional labs for fundamental research in chemical biology and drug discovery pathways.

Basic Information

Product Name	(R)-6,7-Dimethoxy-4-(3-(Quinoxalin-2-Yloxy)Pyrrolidin-1-Yl)Quinazoline
CAS No.	927691-21-2
Molecular Formula	C₂₄H₂₅N₅O₄
Molecular Weight	447.49 g/mol
Synonyms	(R)-6,7-Dimethoxy-4-[3-(quinoxalin-2-yloxy)pyrrolidin-1-yl]quinazoline; (R)-4-(3-(Quinoxalin-2-yloxy)pyrrolidin-1-yl)-6,7-dimethoxyquinazoline; UNII-9V8P1F3V9I; 927691-21-2; (R)-enantiomer of a quinazoline-quinoxaline hybrid; Pyrrolidinylquinazoline derivative; Kinase inhibitor intermediate
EINECS	Contact for details

Quality Control

Our production of (R)-6,7-Dimethoxy-4-(3-(Quinoxalin-2-Yloxy)Pyrrolidin-1-Yl)Quinazoline adheres to stringent quality management systems, ensuring batch-to-batch consistency for research applications. The material is manufactured under controlled conditions and undergoes comprehensive analytical characterization, including chiral purity verification. Certificates of Analysis (COA) detailing identity, purity (HPLC), and chiral excess are provided with each shipment to support regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C or as specified on the label) in a dry, well-ventilated area. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.