Description

5-Fluoroquinoline-8-Carboxylic Acid is a high-value, multifunctional heterocyclic building block essential for advanced organic synthesis. Its core value lies in its unique molecular architecture, which combines a fluorinated quinoline scaffold with a strategically positioned carboxylic acid group, enabling precise molecular modifications. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients, particularly in medicinal chemistry programs targeting new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those with fluorinated quinoline cores, which are prevalent in antimicrobial and anticancer research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the fluorine atom enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized chelating ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as novel fluorophores or charge-transport molecules, due to its conjugated quinoline system.
• Chemical Biology Probes: Utilized to build fluorescent or bioactive probes for studying biological processes and enzyme mechanisms.
• Custom Synthesis and Contract Manufacturing: A fundamental building block for custom chemical synthesis services catering to R&D and pilot-scale production.

Basic Information

Product Name	5-Fluoroquinoline-8-Carboxylic Acid
CAS No.	926252-31-5
Molecular Formula	C10H6FNO2
Molecular Weight	191.16 g/mol
Synonyms	8-Quinolinecarboxylic acid, 5-fluoro-; 5-Fluoro-8-quinolinecarboxylic acid; 5-Fluoroquinoline-8-carboxylate; 5-Fluoro-8-carboxyquinoline; 926252-31-5; 5-Fluoro-8-quinoline carboxylic acid; 5-Fluoroquinoline-8-carboxylic acid (primary name)
EINECS	Contact for details

Quality Control

Our 5-Fluoroquinoline-8-Carboxylic Acid is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, identity, and impurity profiles. While typically supplied as a high-purity research grade, production can be aligned with specific customer requirements and good laboratory practice (GLP) standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The product is compatible with strong acids and organic solvents but should be kept separate from strong bases and oxidizing agents. Keep the container tightly sealed when not in use to maintain quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Maximum Impurity	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.