Description

Fmoc-2-Amino-5-Iodobenzoic Acid is a high-purity, protected amino acid derivative essential for advanced peptide synthesis and medicinal chemistry research. Its core value lies in providing a versatile, orthogonally protected building block for the solid-phase synthesis of complex peptides and peptidomimetics containing iodinated aromatic residues. This compound is critically needed by pharmaceutical R&D teams, CROs, and fine chemical manufacturers developing novel therapeutic agents, particularly for targeted drug delivery and molecular imaging applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the automated synthesis of peptides containing iodinated tyrosine or phenylalanine analogs.
• Medicinal Chemistry & Drug Discovery: Used in the design and synthesis of peptide-based drug candidates, where the iodine atom serves as a handle for further functionalization (e.g., radioiodination for imaging) or to modulate pharmacokinetic properties.
• Combinatorial Chemistry Libraries: Serves as a valuable building block for creating diverse libraries of compounds for high-throughput screening against biological targets.
• Bioconjugation & Probe Development: The aromatic iodine allows for subsequent cross-coupling reactions (e.g., Sonogashira, Suzuki) to attach fluorescent tags, affinity labels, or other functional groups.
• Material Science & Organic Electronics: Potential precursor for synthesizing organic semiconductors or liquid crystals where halogenated aromatic systems are required.

Basic Information

Item	Details
Product Name	Fmoc-2-Amino-5-Iodobenzoic Acid
CAS No.	924817-95-8
Molecular Formula	C22H16INO4
Molecular Weight	485.27 g/mol
Synonyms	Fmoc-2-Amino-5-iodobenzoic acid; 2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-5-iodobenzoic acid; 5-Iodo-2-[(9-fluorenylmethoxycarbonyl)amino]benzoic acid; N-Fmoc-2-amino-5-iodobenzoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-iodoanthranilic acid; Fmoc-5-Iodoanthranilic Acid; Fmoc-Iodotyrosine precursor; Contact for details on additional synonyms.
EINECS	Contact for details

Quality Control

Our Fmoc-2-Amino-5-Iodobenzoic Acid is manufactured under strict quality control protocols to ensure consistency and high purity for sensitive research and production applications. Each batch is analyzed to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) are provided, detailing results from HPLC, NMR, and other relevant analytical methods. We adhere to cGMP principles where applicable to support our clients in regulated development pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.