Description

(R)-1-Cyclopropyl-7-Fluoro-9-Methyl-8-[3-[1-(Methyl-Piperidin-4-Yl-Amino)-Cyclopropyl]-Pyrrolidin-1-Yl]-4-Oxo-4H-Quinolizine-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with a complex, chiral molecular architecture. This compound is of significant commercial and research interest due to its role as a key building block in the synthesis of novel, potent antibacterial agents, particularly within the quinolone and quinolizine classes. It is primarily required by pharmaceutical R&D laboratories, process development chemists, and manufacturers engaged in the production of next-generation antibiotics targeting resistant bacterial strains.

Application

• Pharmaceutical Intermediate: Critical chiral building block for the synthesis of novel broad-spectrum antibacterial agents.
• Antibiotic R&D: Used in medicinal chemistry research for developing new quinolone and quinolizine derivatives with improved efficacy and safety profiles.
• Process Chemistry: Serves as a key starting material or intermediate in scale-up and optimization of API (Active Pharmaceutical Ingredient) manufacturing processes.
• Biochemical Research: Utilized in studies investigating structure-activity relationships (SAR) and the mechanism of action of bacterial topoisomerase inhibitors.
• GMP Manufacturing: Supplied under controlled conditions for use in cGMP-compliant production of clinical trial materials and commercial APIs.
• Custom Synthesis: Available for contract research organizations (CROs) and CDMOs (Contract Development and Manufacturing Organizations) working on proprietary antibiotic programs.

Basic Information

Product Name	(R)-1-Cyclopropyl-7-Fluoro-9-Methyl-8-[3-[1-(Methyl-Piperidin-4-Yl-Amino)-Cyclopropyl]-Pyrrolidin-1-Yl]-4-Oxo-4H-Quinolizine-3-Carboxylic Acid
CAS No.	922718-09-0
Molecular Formula	C29H38FN5O3
Molecular Weight	523.65 g/mol
Synonyms	(R)-1-Cyclopropyl-7-fluoro-9-methyl-8-[3-[1-[(4-methylpiperazin-1-yl)methyl]cyclopropyl]pyrrolidin-1-yl]-4-oxo-4H-quinolizine-3-carboxylic acid; (R)-1-Cyclopropyl-7-fluoro-9-methyl-8-[3-[1-(methyl-piperazin-1-yl-methyl)-cyclopropyl]-pyrrolidin-1-yl]-4-oxo-4H-quinolizine-3-carboxylic acid; Quinolizine-3-carboxylic acid derivative; Antibacterial intermediate 922718-09-0; (R)-enantiomer of a quinolizine antibiotic precursor; (R)-configuration fluoroquinolone analog; Advanced chiral fluoroquinolone intermediate.
EINECS	Contact for details

Quality Control

Our (R)-1-Cyclopropyl-7-Fluoro-9-Methyl-8-[3-[1-(Methyl-Piperidin-4-Yl-Amino)-Cyclopropyl]-Pyrrolidin-1-Yl]-4-Oxo-4H-Quinolizine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, assay determination, and identification of related substances and impurities. We provide detailed Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with customer specifications and relevant ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in the original sealed container to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% (R-isomer)
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.