Description

tert-Butyl 6-Cyano-4-Oxospiro[Chroman-2,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic and piperidine-based molecular architecture. This compound is of critical importance for research and development in medicinal chemistry, serving as a sophisticated building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical companies and contract research organizations (CROs) engaged in the development of new therapeutic agents, particularly within central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of complex drug candidates, especially those targeting neurological disorders.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Integral in constructing the final molecular framework of potential new chemical entities (NCEs) under Good Laboratory Practice (GLP) conditions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and cGMP (current Good Manufacturing Practice) production.
• Biochemical Tool Compound: May be utilized in biochemical assays to study enzyme inhibition or receptor binding mechanisms.

Basic Information

Product Name	tert-Butyl 6-Cyano-4-Oxospiro[Chroman-2,4'-Piperidine]-1'-Carboxylate
CAS No.	921760-47-6
Molecular Formula	C19H22N2O4
Molecular Weight	342.39 g/mol
Synonyms	1'-Boc-6-cyano-4-oxospiro[chroman-2,4'-piperidine]; 1'-tert-Butoxycarbonyl-6-cyano-4-oxospiro[chroman-2,4'-piperidine]; 6-Cyano-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylic acid tert-butyl ester; tert-Butyl 6-cyano-4-oxospiro[2H-chromene-2,4'-piperidine]-1'-carboxylate; Spiro[chroman-2,4'-piperidine]-1'-carboxylic acid, 6-cyano-4-oxo-, 1,1-dimethylethyl ester; Boc-6-cyano-4-oxospiro[chroman-2,4'-piperidine]
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Cyano-4-Oxospiro[Chroman-2,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.