Description

3-Quinolinecarboxaldehyde, 2-Chloro-8-(Trifluoromethyl)- is a high-purity, multi-functional heterocyclic building block. This compound is valued for its unique molecular scaffold, which combines a quinoline core with chloro and trifluoromethyl substituents, enabling precise structural modifications in advanced synthesis. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science: Serves as a building block for creating advanced organic electronic materials, such as ligands for OLEDs and charge-transport molecules.
• Chemical Synthesis: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and as a formylating agent for introducing aldehyde functionality into complex molecules.
• Ligand & Catalyst Development: Useful for constructing nitrogen-containing ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Item	Detail
Product Name	3-Quinolinecarboxaldehyde, 2-Chloro-8-(Trifluoromethyl)-
CAS No.	920494-32-2
Molecular Formula	C11H5ClF3NO
Molecular Weight	259.61 g/mol
Synonyms	2-Chloro-8-(trifluoromethyl)quinoline-3-carboxaldehyde; 2-Chloro-8-trifluoromethylquinoline-3-carbaldehyde; 3-Formyl-2-chloro-8-(trifluoromethyl)quinoline; 2-Chloro-8-(trifluoromethyl)-3-quinolinecarboxaldehyde; 920494-32-2; 2-Chloro-8-trifluoromethyl-3-quinolinecarboxaldehyde
EINECS	Contact for details

Quality Control

Every batch of 3-Quinolinecarboxaldehyde, 2-Chloro-8-(Trifluoromethyl)- is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, NMR, and GC-MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and propensity for oxidation, it is recommended to handle under an inert atmosphere for long-term storage and to minimize headspace in opened containers.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.