Description

2,2,2-Trifluoro-n-((5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Methyl)Ethanamine Hydrochloride is a high-value, multifunctional chemical building block that combines a pyridine core with a pinacol boronate ester and a trifluoroethylamine hydrochloride moiety. This compound matters because it serves as a critical intermediate in modern synthetic chemistry, enabling the construction of complex molecules through versatile cross-coupling and functionalization reactions. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for drug discovery, process development, and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester group makes it an excellent reagent for forming carbon-carbon bonds with aryl/heteroaryl halides, a cornerstone of medicinal chemistry.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the biological activity often associated with fluorinated and pyridine-containing compounds.
• Material Science Precursor: Potential intermediate for creating advanced organic electronic materials, ligands for catalysts, or metal-organic frameworks (MOFs).
• Chemical Biology & Proteomics: Can be utilized as a probe or linker in bioconjugation strategies due to its reactive amine and boronic acid ester functionalities.
• Process Chemistry & Scale-up: Serves as a reliable starting material for the kilogram-scale production of target molecules under Good Manufacturing Practice (GMP) guidelines where applicable.

Basic Information

Item	Details
Product Name	2,2,2-Trifluoro-n-((5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Methyl)Ethanamine Hydrochloride
CAS No.	919347-59-4
Molecular Formula	C16H25BClF3N2O2
Molecular Weight	380.64 g/mol
Synonyms	5-((2,2,2-Trifluoroethylamino)methyl)pyridine-3-boronic acid pinacol ester hydrochloride; 3-(((2,2,2-Trifluoroethyl)amino)methyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine hydrochloride; 2,2,2-Trifluoro-N-((5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methyl)ethan-1-amine hydrochloride; 919347-59-4; Trifluoroethylaminomethylpyridinyl boronic ester HCl; (5-((2,2,2-Trifluoroethylamino)methyl)pyridin-3-yl)boronic acid pinacol ester hydrochloride
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-n-((5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Methyl)Ethanamine Hydrochloride is produced under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity, identity confirmation, and batch-to-batch consistency. Standard testing includes HPLC for assay and purity, NMR and IR for structural confirmation, and KF titration for water content. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions, such as in a glovebox or under an inert atmosphere, for long-term storage or when opening the primary container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (Titration)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.