Description

1,9-Diazaspiro[5.5]Undecane-9-Carboxylic Acid, 1-(2,2,2-Trifluoroacetyl)-, 1,1-Dimethylethyl Ester is a sophisticated spirocyclic building block featuring a protected carboxylic acid and a trifluoroacetylated secondary amine. This compound matters as a versatile and high-value intermediate for constructing complex nitrogen-containing molecular architectures, particularly in pharmaceutical discovery. It is primarily needed by medicinal chemistry and process R&D teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of spirocyclic drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Scaffold: Used in combinatorial chemistry and parallel synthesis libraries to explore novel chemical space and structure-activity relationships (SAR).
• Protease Inhibitor Core: Serves as a constrained scaffold in the development of inhibitors for various proteolytic enzymes.
• Agrochemical Research: Employed in the discovery of new herbicides, fungicides, or insecticides that utilize spirocyclic motifs for enhanced bioactivity and stability.
• Chemical Biology Probe: Utilized as a tagged or functionalized core structure for studying protein-ligand interactions and biological pathways.
• Advanced Material Synthesis: Potential precursor for specialty polymers or ligands in catalysis, leveraging its rigid, three-dimensional structure.

Basic Information

Item	Details
Product Name	1,9-Diazaspiro[5.5]Undecane-9-Carboxylic Acid, 1-(2,2,2-Trifluoroacetyl)-, 1,1-Dimethylethyl Ester
CAS No.	918896-27-2
Molecular Formula	C16H25F3N2O3
Molecular Weight	350.38 g/mol
Synonyms	tert-Butyl 1-(2,2,2-trifluoroacetyl)-1,9-diazaspiro[5.5]undecane-9-carboxylate; 1,9-Diazaspiro[5.5]undecane-9-carboxylic acid, 1-(trifluoroacetyl)-, 1,1-dimethylethyl ester; 1-(2,2,2-Trifluoroacetyl)-1,9-diazaspiro[5.5]undecane-9-carboxylic acid tert-butyl ester; 1,9-Diazaspiro[5.5]undecane-9-carboxylic acid, 1-(trifluoroacetyl)-, tert-butyl ester; 1-N-(Trifluoroacetyl)-9-N-(tert-butoxycarbonyl)-1,9-diazaspiro[5.5]undecane; BOC-1,9-Diazaspiro[5.5]undecane-9-carboxylic acid, 1-TFA protected; 918896-27-2
EINECS	Contact for details

Quality Control

Our 1,9-Diazaspiro[5.5]Undecane-9-Carboxylic Acid, 1-(2,2,2-Trifluoroacetyl)-, 1,1-Dimethylethyl Ester is produced under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and internal standards. Our commitment to cGMP principles ensures reliability for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere if necessary to prevent moisture uptake and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.