Description

3H-Pyrrolo[2,3-C]Quinoline-1-Carboxylic Acid, 8-(Chlorosulfonyl)-4,5-Dihydro-4-Oxo- is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its complex fused-ring structure, featuring both a quinoline core and a pyrrole moiety, along with reactive chlorosulfonyl and carboxylic acid groups, makes it a versatile precursor for constructing sophisticated molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in the development of kinase inhibitors and other targeted therapies.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of novel drug candidates, especially in oncology and anti-inflammatory research.
• Kinase Inhibitor Scaffold: Serves as a core structural element in the design and synthesis of small molecule kinase inhibitors due to its privileged heterocyclic framework.
• Agrochemical Research: Used in the discovery and synthesis of new active ingredients for crop protection products.
• Chemical Biology Probe Development: Employed in the creation of molecular probes to study biological pathways and protein functions.
• Advanced Material Synthesis: Potential building block for creating organic electronic materials or specialty dyes with unique photophysical properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	3H-Pyrrolo[2,3-C]Quinoline-1-Carboxylic Acid, 8-(Chlorosulfonyl)-4,5-Dihydro-4-Oxo-
CAS No.	918473-13-9
Molecular Formula	C12H7ClN2O5S
Molecular Weight	326.71 g/mol
Synonyms	8-(Chlorosulfonyl)-4,5-dihydro-4-oxo-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid; 1-Carboxy-8-chlorosulfonyl-4,5-dihydro-4-oxo-3H-pyrrolo[2,3-c]quinoline; 918473-13-9; Pyrroloquinoline-1-carboxylic acid, 8-(chlorosulfonyl)-4,5-dihydro-4-oxo-; 3H-Pyrrolo[2,3-c]quinoline-1-carboxylic acid, 8-(chlorosulfonyl)-4,5-dihydro-4-oxo-
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications such as assay, impurity profile, and residual solvents. We support cGMP-compliant manufacturing for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.