Description

2S-7-Aza-Bicyclo[2.2.1]Heptane-2,7-Dicarboxylic Acid 7-tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a rigid, constrained bicyclic structure. This compound is valued for its role as a key chiral building block in the synthesis of complex molecules, particularly in medicinal chemistry. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, including protease inhibitors and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A critical chiral scaffold in the research and development of novel drug candidates, especially for targeting specific enzymes and receptors.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization due to its constrained geometry and stereochemical definition.
• Protease Inhibitor Synthesis: Serves as a core structural element in the preparation of potential protease inhibitors for virology and oncology applications.
• Asymmetric Synthesis: Employed as a sophisticated building block to introduce chiral complexity and conformational restraint into target molecules.
• Chemical Biology Research: Utilized in the design and synthesis of chemical probes for studying biological pathways and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2S-7-Aza-Bicyclo[2.2.1]Heptane-2,7-Dicarboxylic Acid 7-tert-Butyl Ester
CAS No.	918411-46-8
Molecular Formula	C12H19NO4
Molecular Weight	241.29 g/mol
Synonyms	(2S)-7-Azabicyclo[2.2.1]heptane-2,7-dicarboxylic acid 7-(1,1-dimethylethyl) ester; 7-tert-Butyl 2S-7-azabicyclo[2.2.1]heptane-2,7-dicarboxylate; (1S,4S)-2-Azabicyclo[2.2.1]heptane-3-carboxylic acid, 1-(tert-butoxycarbonyl)-; 7-Boc-2-aza-norbornane-2,7-dicarboxylic acid (2S isomer); 7-Aza-2-norbornanecarboxylic acid, 7-(tert-butoxycarbonyl)-, (2S)-; tert-Butyl (2S)-7-azabicyclo[2.2.1]heptane-2,7-dicarboxylate; (2S)-7-(tert-Butoxycarbonyl)-7-azabicyclo[2.2.1]heptane-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 2S-7-Aza-Bicyclo[2.2.1]Heptane-2,7-Dicarboxylic Acid 7-tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity and chemical identity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.