Description

Methyl 3-(3-Fluorophenyl)-2,4-Dioxo-1,2,3,4-Tetrahydroquinazoline-7-Carboxylate is a high-purity, fluorinated quinazoline derivative serving as a critical advanced pharmaceutical intermediate. This compound matters for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. Pharmaceutical R&D laboratories and fine chemical manufacturers need this precise building block to develop next-generation drug candidates with potential enhanced efficacy and selectivity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug molecules, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core structural unit in the multi-step synthesis of complex fluorinated quinazoline-based APIs.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Biochemical Tool Compound: Employed in biochemical assays to study enzyme inhibition and receptor binding mechanisms.
• Fine Chemical Production: Utilized in the custom synthesis of specialty chemicals for advanced material science applications.

Basic Information

Product Name	Methyl 3-(3-Fluorophenyl)-2,4-Dioxo-1,2,3,4-Tetrahydroquinazoline-7-Carboxylate
CAS No.	917889-24-8
Molecular Formula	C₁₆H₁₁FN₂O₄
Molecular Weight	314.27 g/mol
Synonyms	Methyl 3-(3-fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate; 7-Quinazolinecarboxylic acid, 3-(3-fluorophenyl)-1,2,3,4-tetrahydro-2,4-dioxo-, methyl ester; Methyl 3-(3-fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydro-7-quinazolinecarboxylate; 3-(3-Fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylic acid methyl ester; 917889-24-8; Methyl 3-(3-fluorophenyl)-2,4-dioxo-3,4-dihydro-1H-quinazoline-7-carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 3-(3-Fluorophenyl)-2,4-Dioxo-1,2,3,4-Tetrahydroquinazoline-7-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.