Description

Methyl 3-(2-Fluorophenyl)-2,4-Dioxo-1,2,3,4-Tetrahydroquinazoline-7-Carboxylate is a high-purity, fluorinated quinazoline derivative serving as a critical advanced pharmaceutical intermediate. This compound matters for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development for oncology, neurology, and other specialized fields.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Organic Synthesis Reference Standard: Used as a pure standard for analytical method development, validation, and quality control in chemical production.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme function and biological pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical clients with custom synthesis and scale-up projects.
• Academic Research: Employed in university and institutional labs for fundamental studies in heterocyclic chemistry and fluorine chemistry.

Basic Information

Product Name	Methyl 3-(2-Fluorophenyl)-2,4-Dioxo-1,2,3,4-Tetrahydroquinazoline-7-Carboxylate
CAS No.	917889-23-7
Molecular Formula	C₁₆H₁₁FN₂O₄
Molecular Weight	314.27 g/mol
Synonyms	7-Carbomethoxy-3-(2-fluorophenyl)-1,2,3,4-tetrahydro-2,4-quinazolinedione; Methyl 3-(2-fluorophenyl)-1,2,3,4-tetrahydro-2,4-dioxoquinazoline-7-carboxylate; 3-(2-Fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylic acid methyl ester; 2,4(1H,3H)-Quinazolinedione, 3-(2-fluorophenyl)-1,2,3,4-tetrahydro-7-(methoxycarbonyl)-; 7-Methoxycarbonyl-3-(2-fluorophenyl)-1,2,3,4-tetrahydroquinazoline-2,4-dione
EINECS	Contact for details

Quality Control

Our Methyl 3-(2-Fluorophenyl)-2,4-Dioxo-1,2,3,4-Tetrahydroquinazoline-7-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.