Description

4-Amino-2,8-Bis(Trifluoromethyl)-Quinoline is a high-value, fluorinated quinoline derivative, distinguished by its trifluoromethyl groups which impart unique electronic and steric properties. This compound is critical for advanced research and development, particularly in the synthesis of complex molecules where fluorine substitution is required to modulate biological activity, lipophilicity, and metabolic stability. It serves as a key synthetic intermediate for pharmaceutical chemists and agrochemical researchers developing new active ingredients, as well as for material scientists exploring novel organic electronic materials.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the trifluoromethyl groups enhance bioavailability and environmental stability.
• Material Science Precursor: Serves as a monomer or functional component in the creation of advanced organic semiconductors, liquid crystals, and fluorinated polymers.
• Chemical Biology Probe: Employed in the design of molecular probes and fluorescent tags for studying biological systems and diagnostic applications.
• Catalyst Ligand Synthesis: The quinoline nitrogen and amino group provide a versatile scaffold for constructing specialized ligands used in homogeneous catalysis.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis and fluorine chemistry within university and corporate research laboratories.

Basic Information

Product Name	4-Amino-2,8-Bis(Trifluoromethyl)-Quinoline
CAS No.	917561-99-0
Molecular Formula	C₁₂H₆F₆N₂
Molecular Weight	292.19 g/mol
Synonyms	2,8-Bis(trifluoromethyl)quinolin-4-amine; 4-Amino-2,8-bis(trifluoromethyl)quinoline; Quinoline, 4-amino-2,8-bis(trifluoromethyl)-; 917561-99-0; 4-Amino-2,8-di(trifluoromethyl)quinoline; 2,8-Bis(trifluoromethyl)-4-quinolinamine
EINECS	Contact for details

Quality Control

Every batch of 4-Amino-2,8-Bis(Trifluoromethyl)-Quinoline is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is sensitive to strong alkalis and fluorides; keep away from incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.