Description

4-Quinazolineacetic Acid, 8-Fluoro-3,4-Dihydro-2-[4-(3-Methoxyphenyl)-1-Piperazinyl]-3-[2-Methoxy-5-(Trifluoromethyl)Phenyl]-, Methyl Ester, (4S)- is a high-purity, advanced pharmaceutical intermediate with a complex, multi-ring structure. This compound is of significant interest for its role as a key building block in the research and development of novel therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of targeted, small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of investigational new drugs (INDs) and new chemical entities (NCEs).
• Oncology Research: Used in the development of targeted kinase inhibitors and other anti-cancer compounds due to its quinazoline core.
• CNS Drug Discovery: Applied in research programs focused on neurological disorders, leveraging its structural features for blood-brain barrier penetration.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and cGMP manufacturing of active pharmaceutical ingredients (APIs).
• Academic & Institutional Research: Utilized in university and government labs for biochemical and pharmacological studies.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	4-Quinazolineacetic Acid, 8-Fluoro-3,4-Dihydro-2-[4-(3-Methoxyphenyl)-1-Piperazinyl]-3-[2-Methoxy-5-(Trifluoromethyl)Phenyl]-, Methyl Ester, (4S)-
CAS No.	917389-29-8
Molecular Formula	C31H30F4N4O4
Molecular Weight	598.59 g/mol
Synonyms	(4S)-8-Fluoro-3,4-dihydro-2-[4-(3-methoxyphenyl)-1-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-4-quinazolineacetic acid methyl ester; Methyl (4S)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazoline-4-acetate; 917389-29-8; (S)-Enantiomer of a quinazoline piperazine derivative; Advanced pharmaceutical intermediate 917389-29-8.
EINECS	Contact for details

Quality Control

Our 4-Quinazolineacetic Acid derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data, residual solvent analysis, and full characterization (NMR, MS) are provided to guarantee traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.