Description

4-Quinazolineacetic Acid, 8-Fluoro-1,2,3,4-Tetrahydro-3-[2-Methoxy-5-(Trifluoromethyl)Phenyl]-2-Oxo-, Methyl Ester is a high-purity, complex heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a sophisticated intermediate, offering a unique molecular scaffold that combines a quinazolinone core with fluorinated and methoxy-substituted aromatic moieties. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for targeting neurological and oncological pathways.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Chemical Biology Probes: Employed in the development of specialized molecular probes for studying enzyme function and cellular signaling pathways.
• Advanced Organic Synthesis: Acts as a key building block for constructing complex, polyfunctional heterocyclic compounds in academic and industrial research.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the life sciences industry.

Basic Information

Product Name	4-Quinazolineacetic Acid, 8-Fluoro-1,2,3,4-Tetrahydro-3-[2-Methoxy-5-(Trifluoromethyl)Phenyl]-2-Oxo-, Methyl Ester
CAS No.	917389-21-0
Molecular Formula	C20H16F4N2O4
Molecular Weight	424.35 g/mol
Synonyms	Methyl 8-fluoro-3-[2-methoxy-5-(trifluoromethyl)phenyl]-2-oxo-1,2,3,4-tetrahydro-4-quinazolineacetate; 8-Fluoro-1,2,3,4-tetrahydro-3-[2-methoxy-5-(trifluoromethyl)phenyl]-2-oxo-4-quinazolineacetic acid methyl ester; 917389-21-0; CAS 917389-21-0; Quinazolinone derivative intermediate; Fluorinated quinazoline ester.
EINECS	Contact for details

Quality Control

Our 4-Quinazolineacetic Acid, 8-Fluoro-1,2,3,4-Tetrahydro-3-[2-Methoxy-5-(Trifluoromethyl)Phenyl]-2-Oxo-, Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request, supporting compliance in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.