Description

8-Chloro-5-Fluoro-2-(Trifluoromethyl)Quinolin-4-Ol is a high-value, multi-functionalized quinoline derivative that serves as a critical building block in advanced organic synthesis. Its unique halogenated and trifluoromethylated structure makes it indispensable for creating novel compounds with tailored biological and physical properties. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology, antiviral, and anti-inflammatory research pipelines.
• Agrochemical Synthesis: Used to develop advanced active ingredients for crop protection products, leveraging the fluorine and chlorine substituents for enhanced efficacy and environmental profile.
• Material Science Research: Serves as a building block for creating specialty chemicals, dyes, and functional materials with specific electronic or photophysical properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and contract research organizations (CROs/CMOs) specializing in fluorinated heterocycles.

Basic Information

Product Name	8-Chloro-5-Fluoro-2-(Trifluoromethyl)Quinolin-4-Ol
CAS No.	917251-94-6
Molecular Formula	C₁₀H₄ClF₄NO
Molecular Weight	265.59 g/mol
Synonyms	8-Chloro-5-fluoro-2-(trifluoromethyl)-4-quinolinol; 4-Quinolinol, 8-chloro-5-fluoro-2-(trifluoromethyl)-; 8-Chloro-5-fluoro-2-(trifluoromethyl)quinolin-4-ol; 917251-94-6; 8-Chloro-5-fluoro-2-trifluoromethylquinolin-4-ol; 4-Hydroxy-8-chloro-5-fluoro-2-(trifluoromethyl)quinoline
EINECS	Contact for details

Quality Control

Our 8-Chloro-5-Fluoro-2-(Trifluoromethyl)Quinolin-4-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is sensitive to fluoride and strong alkali; ensure it is stored separately from such materials to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.