Description

8-Bromo-5-(trifluoromethyl)quinoline is a high-value, multi-functional halogenated quinoline derivative. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and material science industries for developing novel active compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Research: Used as a core scaffold for developing new generation herbicides, fungicides, and pesticides, leveraging the biological activity of the quinoline and trifluoromethyl groups.
• Material Science: Serves as a monomer or functional additive in the development of advanced organic electronic materials, such as OLEDs and conductive polymers.
• Ligand & Catalyst Development: Employed in the creation of novel ligands for transition metal catalysis, useful in cross-coupling and other synthetic transformations.
• Chemical Biology Probe: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a fluorescent tag or probe due to the quinoline core.
• Academic & Industrial R&D: A valuable reagent for synthetic organic chemists in universities and corporate research labs exploring new heterocyclic chemistry.

Basic Information

Item	Details
Product Name	8-Bromo-5-(trifluoromethyl)quinoline
CAS No.	917251-92-4
Molecular Formula	C10H5BrF3N
Molecular Weight	276.06 g/mol
Synonyms	8-Bromo-5-(trifluoromethyl)quinoline; 5-(Trifluoromethyl)-8-bromoquinoline; 8-Bromo-5-trifluoromethylquinoline; Quinoline, 8-bromo-5-(trifluoromethyl)-; 917251-92-4; 8-Br-5-CF3-Quinoline
EINECS	Contact for details

Quality Control

Our 8-Bromo-5-(trifluoromethyl)quinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability for your R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (HPLC)	≥ 98.0% / ≥ 99.0% (High Purity Grades)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.