Description

8-Chloro-5-Fluoroquinoline is a high-value, multi-functional halogenated quinoline derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a versatile precursor in the development of active pharmaceutical ingredients (APIs), particularly within the quinolone and fluoroquinolone antibiotic classes. Industries that need it include pharmaceutical R&D, agrochemical manufacturing, and specialty chemical producers focused on creating novel heterocyclic compounds for various applications.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel fluoroquinolone antibiotics and other biologically active molecules.
• Agrochemical Research: Used in the development of new fungicides and herbicides that leverage the quinoline scaffold.
• Material Science: Serves as a precursor for organic ligands in catalytic systems or for creating functionalized materials.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce complex quinoline structures.
• Academic & Industrial R&D: A valuable reagent for medicinal chemistry programs and structure-activity relationship (SAR) studies.

Basic Information

Product Name	8-Chloro-5-Fluoroquinoline
CAS No.	917251-76-4
Molecular Formula	C9H5ClFN
Molecular Weight	181.59 g/mol
Synonyms	5-Fluoro-8-chloroquinoline; 8-Chloro-5-fluoroquinoline; Quinoline, 8-chloro-5-fluoro-; 917251-76-4; FCQ; 8-Cl-5-F-quinoline
EINECS	Contact for details

Quality Control

Our 8-Chloro-5-Fluoroquinoline is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical and research applications. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.