Description

Methyl 2-(4-Chloro-2-Fluorophenyl)Acetate is a high-purity fluorinated aromatic ester building block of significant importance in advanced organic synthesis. Its core value lies in providing a versatile and reactive intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for research chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and novel materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, where the chloro-fluoro substitution pattern enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated aromatic cores in electronic and optoelectronic materials.
• Cross-Coupling Reactions: The ester group can be hydrolyzed to the corresponding acid or transformed into other functional groups for use in Suzuki, Heck, and other palladium-catalyzed couplings.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP guidelines.
• Academic & Industrial R&D: Utilized in medicinal chemistry labs for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	Methyl 2-(4-Chloro-2-Fluorophenyl)Acetate
CAS No.	917023-04-2
Molecular Formula	C9H8ClFO2
Molecular Weight	202.61 g/mol
Synonyms	(4-Chloro-2-fluorophenyl)acetic acid methyl ester; Methyl (4-chloro-2-fluorophenyl)acetate; 2-(4-Chloro-2-fluorophenyl)acetic acid methyl ester; Methyl 4-chloro-2-fluorobenzeneacetate; 4-Chloro-2-fluorobenzeneacetic acid methyl ester; Methyl α-(4-chloro-2-fluorophenyl)acetate
EINECS	Contact for details

Quality Control

Our Methyl 2-(4-Chloro-2-Fluorophenyl)Acetate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and heat sources.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.