Description

tert-Butyl 4-(Chloromethyl)Phenylcarbamate is a high-purity organic building block and pharmaceutical intermediate of significant commercial importance. This compound is valued for its reactive chloromethyl group and protected amine functionality, enabling its use in the synthesis of complex molecules. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where its molecular scaffold contributes to bioactive molecule libraries.
• Organic Synthesis Building Block: Serves as a versatile precursor for introducing the 4-(aminomethyl)phenyl moiety into more complex structures via further functional group transformations.
• Peptidomimetics Research: Employed in medicinal chemistry for the design and construction of peptide analogs and other bioisosteres.
• Ligand and Catalyst Development: Utilized in academic and industrial R&D for creating novel ligands and organocatalysts.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	tert-Butyl 4-(Chloromethyl)Phenylcarbamate
CAS No.	916578-53-5
Molecular Formula	C12H16ClNO2
Molecular Weight	241.71 g/mol
Synonyms	4-(Chloromethyl)phenyl Carbamic Acid tert-Butyl Ester; 1-(tert-Butoxycarbonylamino)-4-(chloromethyl)benzene; N-Boc-4-(Chloromethyl)aniline; tert-Butyl N-[4-(Chloromethyl)phenyl]carbamate; Boc-4-(Chloromethyl)aniline; 4-(Boc-amino)benzyl Chloride; N-(tert-Butoxycarbonyl)-4-(chloromethyl)aniline
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(Chloromethyl)Phenylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistent quality suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.