Description

1,1,3,3-Tetramethylurea is a high-purity, aprotic polar solvent and versatile chemical intermediate with the CAS registry number 632-22-4. Its unique structure, featuring four methyl groups, provides excellent solvating power, thermal stability, and low nucleophilicity, making it a critical reagent in advanced synthesis and formulation processes. This compound is essential for industries such as pharmaceuticals, agrochemicals, and polymer research, where it serves as a reaction medium, catalyst, and coupling agent.

Application

• Pharmaceutical Synthesis: Used as a polar aprotic solvent and reaction medium in the production of active pharmaceutical ingredients (APIs), particularly for peptide coupling and other condensation reactions.
• Agrochemical Formulation: Acts as a solvent and stabilizer in the manufacture of pesticides, herbicides, and plant growth regulators.
• Polymer Chemistry: Serves as a catalyst and solvent in polyurethane and polyimide production, as well as in the synthesis of specialty polymers and resins.
• Chemical Intermediate: A key building block in organic synthesis for creating complex molecules, including dyes, pigments, and photographic chemicals.
• Analytical Chemistry: Employed as a mobile phase modifier in high-performance liquid chromatography (HPLC) due to its solvent properties.
• Electrolyte Additive: Investigated for use in lithium-ion battery electrolytes to enhance conductivity and stability.
• Laboratory Reagent: A valuable solvent for NMR spectroscopy and other analytical techniques where a non-deuterated, inert solvent is required.

Basic Information

Product Name	1,1,3,3-Tetramethylurea
CAS No.	632-22-4
Molecular Formula	C6H14N2O
Molecular Weight	130.19 g/mol
Synonyms	TMU; Tetramethylurea; N,N,N',N'-Tetramethylurea; 1,1,3,3-Tetramethylurea; Urea, tetramethyl-; Urea, N,N,N',N'-tetramethyl-; NSC 60529; Perchloric acid salt of tetramethylurea; TMU (solvent)
EINECS	211-174-2

Quality Control

Our 1,1,3,3-Tetramethylurea is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including gas chromatography (GC) and Karl Fischer titration, to ensure it meets the highest standards of purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment to guarantee reliable performance in your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, open flames, and strong oxidizing agents. The container should be kept tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.449 - 1.453
Density (20°C)	0.965 - 0.975 g/mL
Boiling Point	174 - 177 °C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.