Description

(R)-1-Boc-3-Aminomethylpyrrolidine-Hcl CAS NO 916214-31-8 is a high-purity chiral building block and protected amine derivative, essential for the synthesis of complex pharmaceutical intermediates. Its primary value lies in providing a stereochemically defined scaffold for constructing active pharmaceutical ingredients (APIs) and other bioactive molecules. This compound is critically needed by research institutions and pharmaceutical manufacturers engaged in the development of new drugs, particularly in areas requiring precise chiral control.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Peptidomimetics Construction: Used to introduce the (R)-3-aminomethylpyrrolidine moiety into peptide backbones to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Serves as a versatile building block for creating libraries of chiral compounds in medicinal chemistry and drug discovery programs.
• Ligand and Catalyst Preparation: Employed in the development of chiral ligands for asymmetric catalysis and organocatalysts.
• API Development: Integral for the research and scale-up production of candidate drugs targeting central nervous system (CNS) disorders, infectious diseases, and oncology.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	(R)-1-Boc-3-Aminomethylpyrrolidine Hydrochloride
CAS No.	916214-31-8
Molecular Formula	C11H23ClN2O2
Molecular Weight	250.77 g/mol
Synonyms	(R)-1-(tert-Butoxycarbonyl)-3-(aminomethyl)pyrrolidine hydrochloride; (R)-3-(Aminomethyl)-1-Boc-pyrrolidine hydrochloride; (R)-N-Boc-3-aminomethylpyrrolidine HCl; (R)-1-Boc-3-(aminomethyl)pyrrolidine HCl; tert-Butyl (3R)-3-(aminomethyl)pyrrolidine-1-carboxylate hydrochloride; (R)-1-Boc-3-pyrrolidinemethanamine hydrochloride; (R)-3-(Aminomethyl)pyrrolidine-1-carboxylic acid tert-butyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-1-Boc-3-Aminomethylpyrrolidine-Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for advanced research and GMP-grade production. We provide comprehensive analytical data including HPLC/GC purity, chiral purity, and identification via NMR, IR, and mass spectrometry. Certificates of Analysis (COA) are available for every batch, detailing all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.