Description

(S)-1-Boc-3-Aminomethylpyrrolidine-Hcl is a high-purity chiral building block and protected amine intermediate essential for modern pharmaceutical synthesis. Its primary value lies in providing a stereochemically defined scaffold for constructing complex molecules, enabling the development of targeted therapeutics. This compound is critically needed by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development of active pharmaceutical ingredients (APIs), particularly in areas like protease inhibitors and neurological agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, especially protease inhibitors and other small molecule therapeutics.
• Peptidomimetics Research: Used to introduce constrained pyrrolidine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Serves as a versatile building block for constructing molecules with defined stereochemistry in medicinal chemistry programs.
• API Development: Employed in the research and scale-up production of Active Pharmaceutical Ingredients (APIs) requiring a protected aminomethylpyrrolidine moiety.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Ligand Synthesis for Catalysis: Can be used to prepare chiral ligands for asymmetric catalysis applications.

Basic Information

Product Name	(S)-1-Boc-3-Aminomethylpyrrolidine Hydrochloride
CAS No.	916214-30-7
Molecular Formula	C11H23ClN2O2
Molecular Weight	250.77 g/mol
Synonyms	(S)-1-(tert-Butoxycarbonyl)-3-(aminomethyl)pyrrolidine hydrochloride; (S)-3-(Aminomethyl)-1-Boc-pyrrolidine HCl; (S)-N-Boc-3-aminomethylpyrrolidine hydrochloride; (S)-1-Boc-3-(aminomethyl)pyrrolidine HCl; tert-Butyl (S)-3-(aminomethyl)pyrrolidine-1-carboxylate hydrochloride; (3S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-3-pyrrolidinylmethanamine hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-1-Boc-3-Aminomethylpyrrolidine-Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. We adhere to relevant industry standards and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.