Description

6-Amino-4-((3-Chloro-4-(Pyridin-2-Ylmethoxy)Phenyl)Amino)-7-Ethoxyquinoline-3-Carbonitrile (Hydrochloride) is a high-purity, advanced pharmaceutical intermediate with significant research and development value. This compound is critical for medicinal chemistry programs, particularly in the discovery and synthesis of novel kinase inhibitors. It is primarily sought by pharmaceutical R&D laboratories, biotechnology companies, and contract research organizations (CROs) focused on developing targeted therapies for oncology and other disease areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of investigational new drugs (INDs) and active pharmaceutical ingredients (APIs).
• Kinase Inhibitor Research: Serves as a core scaffold for the development of potent and selective small-molecule kinase inhibitors.
• Oncology Drug Discovery: Used in preclinical research for creating targeted cancer therapeutics.
• Biochemical Assay Development: Employed as a reference standard or probe compound in high-throughput screening (HTS) and mechanism-of-action studies.
• Process Chemistry & Scale-Up: Utilized in route scouting, optimization, and pilot-scale manufacturing for clinical trial material.
• Academic Research: Used in university and institutional labs for chemical biology and medicinal chemistry projects.

Basic Information

Product Name	6-Amino-4-((3-Chloro-4-(Pyridin-2-Ylmethoxy)Phenyl)Amino)-7-Ethoxyquinoline-3-Carbonitrile (Hydrochloride)
CAS No.	915942-01-7
Molecular Formula	C24H21ClN6O2 • HCl
Molecular Weight	505.82 g/mol (for hydrochloride salt)
Synonyms	6-Amino-4-[(3-chloro-4-[(2-pyridinylmethoxy)phenyl]amino]-7-ethoxy-3-quinolinecarbonitrile hydrochloride; 6-Amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile monohydrochloride; 915942-01-7; TAE684 Intermediate; NVP-TAE684 Intermediate; ALK Inhibitor Intermediate; 7-Ethoxy-6-amino-4-((3-chloro-4-(2-pyridylmethoxy)phenyl)amino)-3-quinolinecarbonitrile hydrochloride
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up work. Identity, purity, and impurity profiles are verified using advanced analytical techniques including HPLC, LC-MS, and NMR. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support compliance with ICH guidelines for impurities and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to brown solid powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.