Description

2-Butenamide, n-[4-[[3-Chloro-4-(2-Pyridinylmethoxy)Phenyl]Amino]-3-Cyano-7-Ethoxy-6-Quinolinyl]-4-(Methylamino)-, (2E)- is a sophisticated, high-purity organic compound designed for advanced research and development applications. This molecule is valued for its specific structural features, including a quinoline core and a pyridinylmethoxy moiety, which make it a critical pharmaceutical intermediate and a valuable building block in medicinal chemistry. It is primarily sought by R&D teams and process chemists in the pharmaceutical and biotechnology sectors for the synthesis of novel therapeutic agents, particularly in oncology and targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potential active pharmaceutical ingredients (APIs), especially kinase inhibitors.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates.
• Biochemical Research: Serves as a reference standard or a probe compound in biochemical assays and target validation studies.
• Process Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale under current Good Manufacturing Practices (cGMP) conditions.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, high-value fine chemicals for clinical trials.

Basic Information

Product Name	2-Butenamide, n-[4-[[3-Chloro-4-(2-Pyridinylmethoxy)Phenyl]Amino]-3-Cyano-7-Ethoxy-6-Quinolinyl]-4-(Methylamino)-, (2E)-
CAS No.	915788-27-1
Molecular Formula	C29H26ClN5O3
Molecular Weight	528.00 g/mol
Synonyms	N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(methylamino)-2-butenamide; (2E)-N-[4-[[3-Chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(methylamino)but-2-enamide; BIBW 2992 impurity; Afatinib impurity; Afatinib intermediate; Giotrif intermediate; Gilotrif intermediate; Tyrosine kinase inhibitor intermediate
EINECS	Contact for details

Quality Control

Every batch of this high-value intermediate is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, supporting your regulatory filings. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming compliance with client specifications and industry standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.