Description

5-Bromo-Quinazoline-2,4-Diamine is a high-purity, advanced pharmaceutical intermediate characterized by its brominated quinazoline-diamine core structure. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for synthesizing targeted kinase inhibitors and other biologically active molecules. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for creating novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of targeted anticancer agents, particularly tyrosine kinase inhibitors.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Tool Compound: Serves as a core structure for developing selective enzyme inhibitors used in biological pathway research.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses to introduce the bromo-quinazoline pharmacophore into more complex molecules.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations for the production of clinical trial materials and active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for investigating novel heterocyclic chemistry and drug mechanisms.

Basic Information

Product Name	5-Bromo-Quinazoline-2,4-Diamine
CAS No.	915402-34-5
Molecular Formula	C8H7BrN4
Molecular Weight	239.07 g/mol
Synonyms	2,4-Diamino-5-bromoquinazoline; 5-Bromo-2,4-diaminoquinazoline; 5-Bromoquinazoline-2,4-diamine; Quinazoline-2,4-diamine, 5-bromo-; 915402-34-5; 5-Br-QDA
EINECS	Contact for details

Quality Control

Our 5-Bromo-Quinazoline-2,4-Diamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from prolonged exposure.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.