Description

3-Quinolinecarbonitrile, 8-Chloro-4-[(3-Chloro-4-Fluorophenyl)Amino]-6-Nitro- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the synthesis of targeted therapeutic agents, offering researchers and manufacturers a reliable building block for complex molecular architectures. It is primarily utilized by pharmaceutical R&D and production facilities engaged in developing novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel, targeted small-molecule drugs, particularly in oncology and other therapeutic areas.
• Chemical Research & Development: Serves as a crucial precursor for medicinal chemists exploring new chemical entities and structure-activity relationships.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in multi-step synthetic routes for the production of complex final APIs.
• Biochemical Research: Potential use as a tool compound or inhibitor in biochemical and pharmacological studies due to its specific structural motifs.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.

Basic Information

Product Name	3-Quinolinecarbonitrile, 8-Chloro-4-[(3-Chloro-4-Fluorophenyl)Amino]-6-Nitro-
CAS No.	915369-47-0
Molecular Formula	C₁₆H₈Cl₂FN₃O₂
Molecular Weight	376.16 g/mol
Synonyms	8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-nitroquinoline-3-carbonitrile; 8-Chloro-4-((3-chloro-4-fluorophenyl)amino)-6-nitro-3-quinolinecarbonitrile; 915369-47-0; 4-[(3-Chloro-4-fluorophenyl)amino]-8-chloro-6-nitroquinoline-3-carbonitrile; 8-Chloro-4-(3-chloro-4-fluoroanilino)-6-nitroquinoline-3-carbonitrile; 6-Nitro-8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-3-quinolinecarbonitrile
EINECS	Contact for details

Quality Control

Our production of 3-Quinolinecarbonitrile, 8-Chloro-4-[(3-Chloro-4-Fluorophenyl)Amino]-6-Nitro- adheres to stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications and supporting cGMP requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.