Description

6-Fluoro-3-[(4-Methylpiperazin-1-Yl)Carbonyl]Quinolin-4-Ol is a high-purity, advanced pharmaceutical intermediate featuring a quinoline core substituted with a fluoro group and a 4-methylpiperazine carboxamide moiety. This compound is valued for its role as a critical building block in the synthesis of novel, targeted therapeutic agents, particularly in oncology and other disease areas. It is essential for research institutions, contract research organizations (CROs), and pharmaceutical companies engaged in drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other small-molecule drug candidates targeting specific biological pathways.
• Drug Discovery & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization processes.
• Biochemical Research: Serves as a reference standard or a tool compound in pharmacological and biochemical assays to study enzyme inhibition.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up synthesis under cGMP conditions for clinical trial material production.

Basic Information

Product Name	6-Fluoro-3-[(4-Methylpiperazin-1-Yl)Carbonyl]Quinolin-4-Ol
CAS No.	914658-84-7
Molecular Formula	C16H18FN3O2
Molecular Weight	303.33 g/mol
Synonyms	4-Hydroxy-6-fluoro-3-(4-methylpiperazine-1-carbonyl)quinoline; 6-Fluoro-4-hydroxy-3-[(4-methyl-1-piperazinyl)carbonyl]quinoline; 6-Fluoro-3-(4-methylpiperazine-1-carbonyl)quinolin-4-ol; 914658-84-7; 6-Fluoro-3-[(4-methylpiperazin-1-yl)carbonyl]-4-quinolinol
EINECS	Contact for details

Quality Control

Our 6-Fluoro-3-[(4-Methylpiperazin-1-Yl)Carbonyl]Quinolin-4-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.