Description

8-(4-Fluoro-2-Nitrophenyl)-1,4-Dioxa-8-Azaspiro[4.5]Decane is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and other therapeutic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in innovative drug discovery and process chemistry.

Application

• Key Intermediate in API Synthesis: Serves as a crucial building block for the production of novel pharmaceutical compounds, especially those targeting neurological pathways.
• Drug Discovery & Medicinal Chemistry: Used in research and development for constructing complex molecular scaffolds to explore new biological activities.
• Process Chemistry & Scale-Up: Employed in the optimization and commercial-scale manufacturing of candidate drugs.
• Precursor for Spirocyclic Compounds: The protected spirocyclic amine structure is a versatile precursor for further functionalization in organic synthesis.

Basic Information

Product Name	8-(4-Fluoro-2-Nitrophenyl)-1,4-Dioxa-8-Azaspiro[4.5]Decane
CAS No.	914637-75-5
Molecular Formula	C17H21FN2O4
Molecular Weight	336.36 g/mol
Synonyms	8-(4-Fluoro-2-nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane; 1,4-Dioxa-8-azaspiro[4.5]decane, 8-(4-fluoro-2-nitrophenyl)-; 8-(4-Fluoro-2-nitro-phenyl)-1,4-dioxa-8-aza-spiro[4.5]decane; 8-(4-Fluoro-2-nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane; 914637-75-5; 8-(4-Fluoro-2-nitrophenyl)-1,4-dioxa-8-azaspiro[4,5]decane
EINECS	Contact for details

Quality Control

Our production of 8-(4-Fluoro-2-Nitrophenyl)-1,4-Dioxa-8-Azaspiro[4.5]Decane adheres to stringent quality management systems to ensure batch-to-batch consistency and high purity. All materials are characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.