Description

4-Bromo-1-Fluoro-2-(Methylsulphonyl)Benzene is a high-purity, multi-functional aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromo, fluoro, and methylsulfonyl substituents, makes it a versatile intermediate for constructing complex molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores with electron-withdrawing groups.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and bromine atoms contribute to biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom is an excellent site for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to create complex biaryl structures.
• Sulfone Chemistry: The methylsulfonyl group acts as a strong electron-withdrawing group and can participate in further transformations, such as nucleophilic substitution or as a directing group in metalation reactions.
• Chemical Library Development: Employed in medicinal and combinatorial chemistry for the generation of diverse compound libraries for high-throughput screening.

Basic Information

Product Name	4-Bromo-1-Fluoro-2-(Methylsulphonyl)Benzene
CAS No.	914636-38-7
Molecular Formula	C7H6BrFO2S
Molecular Weight	253.09 g/mol
Synonyms	2-Bromo-5-Fluorophenyl Methyl Sulfone; 1-Bromo-4-Fluoro-2-(Methylsulfonyl)Benzene; 4-Bromo-1-Fluoro-2-(Methanesulfonyl)Benzene; 2-Bromo-5-fluorobenzene-1-sulfonylmethane; Methyl 2-Bromo-5-fluorophenyl sulfone; 914636-38-7; 4-Bromo-1-fluoro-2-(methylsulfonyl)benzene
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-Fluoro-2-(Methylsulphonyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.