Description

6-Chloro-2,3-Difluoro-4-(Trifluoromethyl)Phenylacetic Acid is a high-value, multi-fluorinated aromatic building block essential for advanced chemical synthesis. Its unique structure, featuring chlorine and fluorine substituents on the phenyl ring and a reactive acetic acid side chain, makes it a critical intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by R&D and process development teams in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring fluorinated compounds for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a crucial building block in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved efficacy and environmental profile.
• Liquid Crystal Materials: Used in the synthesis of fluorinated components for electronic display technologies, contributing to desired dielectric and optical properties.
• Organic Electronic Materials: Acts as a precursor for materials used in organic light-emitting diodes (OLEDs) and semiconductors, where fluorination tunes electronic characteristics.
• Advanced Polymer Modification: Employed to introduce fluorinated phenylacetic acid units into polymer chains, enhancing material properties like chemical resistance and thermal stability.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	6-Chloro-2,3-Difluoro-4-(Trifluoromethyl)Phenylacetic Acid
CAS No.	914635-37-3
Molecular Formula	C9H4ClF5O2
Molecular Weight	274.57 g/mol
Synonyms	2-(6-Chloro-2,3-difluoro-4-(trifluoromethyl)phenyl)acetic acid; 6-Chloro-2,3-difluoro-4-(trifluoromethyl)benzeneacetic acid; 2,3-Difluoro-6-chloro-α,α,α,4-tetrafluorotoluic acid (related); (6-Chloro-2,3-difluoro-4-(trifluoromethyl)phenyl)acetic acid; CAS 914635-37-3; 914635-37-3
EINECS	Contact for details

Quality Control

Every batch of 6-Chloro-2,3-Difluoro-4-(Trifluoromethyl)Phenylacetic Acid is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting customer and industry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee supply reliability and batch-to-batch consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.