Description

1-Boc-4-Chloro-3-Hydroxymethylindole is a high-purity, protected indole derivative serving as a critical building block in advanced organic synthesis. This compound is essential for the efficient construction of complex molecular architectures, particularly in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Medicinal Chemistry Research: Used in scaffold hopping and structure-activity relationship (SAR) studies to explore new chemical space around the indole core.
• Peptidomimetic Synthesis: Serves as a protected amino acid analog for constructing complex peptide-like molecules with enhanced metabolic stability.
• Agrochemical Development: Intermediate in the research and production of advanced pesticides and herbicides with novel modes of action.
• Fine Chemical Synthesis: Building block for creating specialty chemicals, dyes, and advanced materials requiring functionalized indole structures.
• Academic & Contract Research: Valuable reagent for methodological development and exploratory synthesis in university and CRO laboratories.

Basic Information

Product Name	1-Boc-4-Chloro-3-Hydroxymethylindole
CAS No.	914349-01-2
Molecular Formula	C14H16ClNO3
Molecular Weight	281.73 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-4-chloro-3-(hydroxymethyl)indole; 4-Chloro-3-(hydroxymethyl)-1H-indole-1-carboxylic acid tert-butyl ester; tert-Butyl 4-chloro-3-(hydroxymethyl)-1H-indole-1-carboxylate; 1-Boc-4-chloroindole-3-methanol; Boc-4-Cl-3-CH2OH-indole; 914349-01-2; 4-Chloro-1H-indole-3-methanol, 1-(1,1-dimethylethyl) ester; 1-N-Boc-4-chloro-3-hydroxymethylindole
EINECS	Contact for details

Quality Control

Our 1-Boc-4-Chloro-3-Hydroxymethylindole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with full analytical data are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.